BDBM50423877 DIHYDROTANSHINONE::Dihydrotanshinone I::acs.jmedchem.1c00409_ST.562

SMILES C[C@H]1COC2=C1C(=O)C(=O)c1c2ccc2c(C)cccc12

InChI Key InChIKey=HARGZZNYNSYSGJ-JTQLQIEISA-N

Data  10 KI  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50423877   

TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50423877(DIHYDROTANSHINONE | Dihydrotanshinone I | acs.jmed...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50423877(DIHYDROTANSHINONE | Dihydrotanshinone I | acs.jmed...)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed